RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
Edn1
RNA ID
RNA Type
mRNA
Alteration Pattern
histone acetylation
Species
rattus norvegicus
Detection Methods
ChIP assay; ET-1 expression in leucocytes; Isolation of peripheral blood leucocytes
Target
NA
Pathway
NA
PubMed ID
Title
Epigenetic changes in peripheral leucocytes as biomarkers in intrauterine growth retardation rat
Year
2016
Function
"Intrauterine growth retardation (IUGR) can cause increased histone acetylation of the endothelin-1 (ET-1) gene from pulmonary vascular endothelial cells or the whole lung tissue and persist into later life,resulting in increased risk of pulmonary hypertension or asthma later in life. The ET-1 protein expression of leucocytes from the 1-week IUGR group was similar to that from the 1-week control group. ET-1 protein expression of leucocytes from 10-week IUGR rats was obviously higher than that of the other groups. The levels of acetylated histone H3 in the ET-1 promoter of leucocytes from the 1-week IUGR rats were significantly higher than those from the age-matched control group. Furthermore, the trends continued <=10 weeks after birth. In conclusion, epigenetic modifications of leucocytes can in part reflect the epigenetic changes of lung tissue in IUGR rats. Epigenetics of peripheral leucocytes may be used as a biomarker for predicting the risk of the development of disease, and may be used as a surrogate to investigate the subsequent development of pulmonary vascular disease or asthma."